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Clinical Weight Loss Trials of Diet PillsDiet Pills Trial - A Comparison of Meridia/Sibutramine and Dexfenfluramine in the Treatment of ObesityAim of Diet Pills Trial 226 healthy outpatients (aged 18 to 65 years; body mass index > or =27 kg/m2) were included in a 12-week, randomized, double-blind, parallel group study. The main outcome measures were changes in weight, body mass index, waist and hip circumference and ratio, and safety profiles. Mean absolute weight loss was 4.5 +/- 0.4 kg in the Meridia/Sibutramine group (n = 112) and 3.2 +/- 0.3 kg in the dexfenfluramine group (n = 112); 4.7 +/- 0.4 kg in the sibutramine group (n = 101); and 3.6 +/- 0.3 kg in the dexfenfluramine group (n = 94). Comparing the two treatments under the conventional null hypothesis of equality as a secondary analysis, weight loss at endpoint in patients receiving sibutramine was significantly greater than that achieved with dexfenfluramine. Both drugs had similar adverse events profiles: 174 patients (77 percent) experienced adverse events; 17 patients withdrew due to adverse events (sibutramine, n = 6; dexfenfluramine, n = 11). Pulse rate increased significantly in sibutramine-treated patients, but decreased in dexfenfluramine-treated patients. Conclusion of Diet Pills Trial Source: Hanotin C, Thomas F, Jones SP, Leutenegger E, Drouin P. Medical Direction,Laboratoires Knoll France-BASF Pharma. Some Clinical Weight Loss Trials of Diet PillsXenical
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