Clinical
Weight Loss Trials of Diet Pills
Clinical Weight Loss Trial of Ephedra-Free
Dietary Supplements
Effects of a Stimulant-Free Weight Loss
Supplement on Body Weight and Fat Loss in Obese
Background
Stimulants, such as ephedrine
and caffeine and their herbal counterparts, have proved effective in facilitating
body weight loss, but their use is controversial due to their undesired
effects. Other dietary supplements
have shown moderate success in reducing body weight, whereas several other
compounds have demonstrated little or no effect. Therefore, a tolerable
and effective nutraceutical that can increase energy expenditure and/or
decrease caloric intake is desirable for body weight reduction.
Aim
Assess the tolerability and effectiveness of a novel, stimulant-free,
dietary supplement containing glucomannan,
chitosan, fenugreek, Gymnema sylvestre, and
vitamin C on body weight and fat loss and change in body composition in
obese adults.
Methods
In this single-center, prospective, randomized, double-blind, placebo-controlled
study conducted at the University of Guelph (Guelph, Ontario, Canada),
obese adults (aged 20-50 years; body mass index [BMI], 30 kg/m2) were
randomized to the treatment or placebo group. The treatment group received
6 capsules of a dietary supplement containing a proprietary blend of glucomannan,
chitosan, fenugreek, G sylvestre, and vitamin C daily for 6 weeks, and
the placebo group received 6 capsules of rice flour daily for 6 weeks.
Results
24 subjects were assigned to the treatment group (8 women, 4 men) or the
placebo group (9 women,3 men). No significant changes in the consumption
of total calories; the percentage of calories ingested as carbohydrates,
fat, or protein; or activity levels were found in either group throughout
the study. Compared with the placebo group, the treatment group lost significantly
more body weight, percentage of body fat, and absolute fat mass. The treatment
group also experienced a significantly greater reduction in upper abdominal
circumference, waist circumference, and hip circumference compared with
the placebo group. No significant changes in heart rate or blood pressure
were found in either group. Both the treatment and the placebo were well
tolerated.
Conclusion
The combination of glucomannan, chitosan, fenugreek, G sylvestre, and
vitamin C results in significant body weight and fat loss in obese adults
within the context of this study.
Source: 2003 Excerpta Medica Inc. All rights
reserved.
Some Clinical Weight Loss Trials of Diet
Pills
Xenical
Diet Pills and Diabesity
Laxatives & Diet Pills
CLA Dietary Pills Trial
Orlistat Diet Pills Trial
Xenical/ Meridia Diet Pills
Xenical/ Orlistat Diet
Pills Trial
Meridia Diet Pills
Meridia & Dexfenfluramine
Sibutramine Diet Pills:
Health Trial
Meridia Diet Pills: Energy
Trial
Sibutramine Diet
Pills: Drug Abuse Trial
Sibutramine Diet Pills Trial
Sibutramine Diet Drugs:
Energy Trial
Orlistat/ Sibutramine
Diet Pills Trial
Orlistat/ Xenical Diet
Pills Trial
Dietary Supplements:
Weight Loss Trial
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